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- Categoria: Area Scientifica
- Scritto da Giulia Pregno
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PubbliTesi - La Tesi
NMDA receptor, Neuregulin/ErbB4 systems and role of Calcium signals in ST14A striatal progenitors migration
Scheda Sintetica
Autore: Giulia Pregno
Relatore: Patrizia Bovolin
Università: Università degli Studi di Torino
Facoltà: Facoltà di Scienze Matematiche, Fisiche e Naturali
Corso: Laurea Spec. in Neurobiologia
Data di Discussione: 07/10/2009
Voto: 110 cum laude
Disciplina: Neurobiologia
Tipo di Tesi: Sperimentale
Lingua: Inglese
Grande Area: Area Scientifica
Dignità di Stampa: Si
Descrizione:
Neuronal migration is a tightly regulated process in which the orchestrated activity of multiple molecules combines to bring about the appropriate allocation of post mitotic neurons. Previous studies have shown that the Neuregulin1(NRG1)/ErbB4 system is involved in several types of neuronal migration. In addition, intracellular calcium fluctuations, often regulated via Ca2+ permeable membrane channels, play central roles in neuronal motility. In this work we examined the possible interactions between a Ca2+ channel, the NMDA-type glutamate receptor, and the NRG1-ErbB4 system in the migratory process of immortalized neural progenitors (ST14A cells).