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- Scritto da Giulia Tempesta
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PubbliTesi - La Tesi
PCSK-9 and vascular smooth muscle cells from insulin-sensitive and insulin-resistant animal model: effect of high glucose.
Scheda Sintetica
Autore: Giulia Tempesta
Relatore: Isabella Russo
Università: Università degli Studi di Torino
Facoltà: Dipartimento di Scienze Mediche
Corso: Laurea Magistrale in Biotecnologie Mediche
Data di Discussione: 19/03/2024
Voto: 110 cum laude
Disciplina: Ematologia molecolare
Tipo di Tesi: Sperimentale
Lingua: Inglese
Grande Area: Area Sanitaria
Dignità di Stampa: Si
Descrizione:
Beyond the regulation of cholesterol metabolism, a number of pleiotropic extrahepatic functions of Proprotein convertase subtilisin/kexin type 9 (PCSK9) have been increasingly identified. An increase of PCSK9 action in vascular smooth muscle cells (VSMC) could play a role in the vascular damage in metabolic disorders, such as obesity and diabetes.
The main purpose of this study was to verify whether PCSK9 expression in VSMC was: (i) affected by insulin-resistance state, (ii) influenced by high glucose exposure, (iii) modulated by PCSK-9 inhibition.