Science

1. Distinct myeloid-derived suppressor cell populations in human glioblastoma | Science
   The role of glioma-associated myeloid cells in tumor growth and immune evasion remains poorly understood. We performed single-cell RNA sequencing of immune and tumor cells from 33 gliomas, identifying two distinct myeloid-derived suppressor cell (MDSC) ...
2. Evolution of interorganismal strigolactone biosynthesis in seed plants | Science
   Strigolactones (SLs) are methylbutenolide molecules derived from β-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical SLs are primarily plant hormones. The cytochrome P450 ...
3. Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis | Science
   The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions orchestrate endocrine system functions remains ...
4. Climate change may be driving spread of a deadly fungus from U.S. Southwest
   Valley fever has exploded since 2000. Scientists are trying to figure out why
5. News at a glance: Oldest continuous ice core, formaldehyde’s risks, and building Africa’s science workforce
   The latest in science and policy