Science

1. Hedonic eating is controlled by dopamine neurons that oppose GLP-1R satiety | Science
   Hedonic eating is defined as food consumption driven by palatability without physiological need. However, neural control of palatable food intake is poorly understood. We discovered that hedonic eating is controlled by a neural pathway from the peri–...
2. Complex-frequency excitations in photonics and wave physics | Science
   Closed, lossless optical cavities are characterized by a Hamiltonian that obeys Hermiticity, resulting in strictly real-valued resonance frequencies. By contrast, non-Hermitian wave systems are characterized by Hamiltonians with poles and zeros at ...
3. Running a genetic stop sign accelerates oxygen metabolism and energy production in horses | Science
   Horses are among nature’s greatest athletes, yet the ancestral molecular adaptations fueling their energy demands are poorly understood. Within a clinically important pathway regulating redox and metabolic homeostasis (NRF2/KEAP1), we discovered an ...
4. Chromatin accessibility landscape of mouse early embryos revealed by single-cell NanoATAC-seq2 | Science
   In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed ...
5. Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins | Science
   Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic datasets, we identified lysosomal leucine aminopeptidase (...