Science

1. Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation | Science
   T cell receptor (TCR) sensitivity to peptide–major histocompatibility complex (MHC) dictates T cell fate. Canonical models of TCR sensitivity cannot be fully explained by transcriptional regulation. In this work, we identify a posttranscriptional ...
2. Exploiting the mechanical effects of ultrasound for noninvasive therapy | Science
   Focused ultrasound is a platform technology capable of eliciting a wide range of biological responses with high spatial precision deep within the body. Although focused ultrasound is already in clinical use for focal thermal ablation of tissue, there has ...
3. Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells | Science
   Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an “eat-me” signal induced by reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as a crucial “don’t ...
4. Durably reducing conspiracy beliefs through dialogues with AI | Science
   Conspiracy theory beliefs are notoriously persistent. Influential hypotheses propose that they fulfill important psychological needs, thus resisting counterevidence. Yet previous failures in correcting conspiracy beliefs may be due to counterevidence ...
5. Microbial dietary preference and interactions affect the export of lipids to the deep ocean | Science
   Lipids comprise a significant fraction of sinking organic matter in the ocean and play a crucial role in the carbon cycle. Despite this, our understanding of the processes that control lipid degradation is limited. We combined nanolipidomics and imaging ...