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A simple high performance liquid chromatography method for therapeutic drug monitoring of isavuconazole and four other antifungal drugs in human plasma samples.

Scheda Sintetica

Autore: Ilaria Zedda
Relatore: Antonio D’Avolio
Università: Università degli Studi di Torino
Facoltà: Dipartimento di Scienze Mediche
Corso: Laurea Magistrale in Biotecnologie Mediche
Data di Discussione: 27/07/2017
Voto: 106
Disciplina: Farmacologia
Tipo di Tesi: Sperimentale
Lingua: Inglese
Grande Area: Area Sanitaria
Dignità di Stampa: Si
Settori Interessati: Medicina, biologia, farmacologia, micologia

Descrizione:
ABSTRACT

Invasive fungal infections are systemic mycoses that usually affect critically ill patients; their treatment is afforded by triazoles, whose Zharmacokinetic properties are still partially unclear.
In particular, isavuconazole (ISC) is a new broad-spectrum antifungal triazole approved in 2015 as first-line treatment for intravenous and oral use against invasive aspergillosis and for mucormycosis.
To date, the optimal management of the treatments with triazoles requires the use of Therapeutic Drug Monitoring (TDM), in order to prevent sub-therapeutic or toxic concentrations. TDM is a routinely used clinical practice that requires reliable quantification methods for benefit from it.
The aim of this work was the development and full validation of a HPLC-mass spectrometry assay for the simultaneous quantification of fluconazole, itraconazole, isavuconazole, posaconazole and voriconazole in human plasma samples, following the FDA (Food and Drug Administration) and EMA (Europea ...