PLOS ONE Alerts: New Articles

1. Correction: The impact of long-term care insurance on family care for older adults: The mediating role of intergenerational financial support

   by The PLOS ONE Staff

2. Construction and practice of a novel pharmaceutical health literacy intervention model in psychiatric hospital

   by Linghe Qiu, Jun Li, Weiming Xie, Fei Wang, Yuan Shen, Jianhong Wu

   Objective

   Pharmaceutical health literacy intervention (PHLI) plays a crucial role in influencing patients’ medical decision-making, particularly concerning medication use. However, PHLI has not been widely implemented in China. This study aims to develop a novel PHLI model within a psychiatric hospital setting and evaluate its effectiveness.

   Methods

   A PHLI model encompassing four modes—covering inpatients, outpatients, Internet+ and community—was established at The Affiliated Mental Health Center of Jiangnan University. The model’s operation was detailed, and its performance data from 2022 and 2023 were evaluated.

   Results

   In 2022 and 2023, a total of 636 PHLI cases were reported. Of these, 386 cases (60.69%) were identified through the inpatient mode. The proportion of PHLI delivered via inpatient and Internet information subscription modes gradually increased, while interventions through other methods decreased. The age group of 18–30 accounted for 21.97% of cases, with 116 instances reported. Various types of PHLI were provided, including adverse reactions (18.87%), dosage and administration (11.64%), and therapeutic drug monitoring (9.43%). In addition, intervention strategies primarily focused on adverse reaction identification (10.22%), interpretation of pharmaceutical reports (7.23%), and routine examination reminders (6.45%).

   Conclusion

   The PHLI model developed at our hospital offers an effective approach to health literacy intervention and represents an innovation advancement in pharmaceutical health literacy management. It can also serve as a reference framework for other hospitals.

3. Correction: Behavioral and genetic correlates of heterogeneity in learning performance in individual honeybees, <i>Apis mellifera</i>

   by The PLOS ONE Staff

4. Transcriptomic signatures of WNT-driven pathways and granulosa cell-oocyte interactions during primordial follicle activation

   by Hinako M. Takase, Tappei Mishina, Tetsutaro Hayashi, Mika Yoshimura, Mariko Kuse, Itoshi Nikaido, Tomoya S. Kitajima

   Primordial follicle activation (PFA) is a pivotal event in female reproductive biology, coordinating the transition from quiescent to growing follicles. This study employed comprehensive single-cell RNA sequencing to gain insights into the detailed regulatory mechanisms governing the synchronized dormancy and activation between granulosa cells (GCs) and oocytes with the progression of the PFA process. Wntless (Wls) conditional knockout (cKO) mice served as a unique model, suppressing the transition from pre-GCs to GCs, and disrupting somatic cell-derived WNT signaling in the ovary. Our data revealed immediate transcriptomic changes in GCs post-PFA in Wls cKO mice, leading to a divergent trajectory, while oocytes exhibited modest transcriptomic alterations. Subpopulation analysis identified the molecular pathways affected by WNT signaling on GC maturation, along with specific gene signatures linked to dormant and activated oocytes. Despite minimal evidence of continuous up-regulation of dormancy-related genes in oocytes, the loss of WNT signaling in (pre-)GCs impacted gene expression in oocytes even before PFA, subsequently influencing them globally. The infertility observed in Wls cKO mice was attributed to compromised GC-oocyte molecular crosstalk and the microenvironment for oocytes. Our study highlights the pivotal role of the WNT-signaling pathway and its molecular signature, emphasizing the importance of intercellular crosstalk between (pre-)GCs and oocytes in orchestrating folliculogenesis.
5. Sustainable logistics development strategy based on SWOT and analytic hierarchy process

   by Changgang Xiao

   Due to the implementation of sustainable green development strategy, the study uses the competitive situation method and analytical hierarchy process of logistics enterprises to conduct structural analysis and weight calculation of factor indicators for their development strategies. Afterwards, the exponential smoothing prediction method was used to weight the logistics data. Moreover, through comparative analysis of the indicator evaluation system, the average weights of the advantageous factors of logistics enterprises were found to be 0.0232, 0.1102, 0.0522, and 0.0468, respectively. The energy consumption, transportation volume, and turnover of logistics transportation increased by 68.9% and 52.3% in 2022, respectively, which had a significant impact on the sustainable development of the logistics industry. It has been demonstrated that a sustainable logistics development strategy based on the enterprise competitive situation method and the analytic hierarchy process is both feasible and superior. Furthermore, this strategy has the potential to enhance the environmental benefits and green development of the economy and society.