Proceedings of the National Academy of Sciences current issue

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Proceedings of the National Academy of Sciences
  1. Cellular and molecular architecture of submucosal glands in wild-type and cystic fibrosis pigs [Cell Biology]
    Submucosal glands (SMGs) protect lungs but can also contribute to disease. For example, in cystic fibrosis (CF), SMGs produce abnormal mucus that disrupts mucociliary transport. CF is an ion transport disease, yet knowledge of the ion transporters expressed by SMG acini, which produce mucus, and SMG ducts that carry it...
  2. Injectable amnion hydrogel-mediated delivery of adipose-derived stem cells for osteoarthritis treatment [Applied Biological Sciences]
    Current treatment strategies for osteoarthritis (OA) predominantly address symptoms with limited disease-modifying potential. There is a growing interest in the use of adipose-derived stem cells (ADSCs) for OA treatment and developing biomimetic injectable hydrogels as cell delivery systems. Biomimetic injectable hydrogels can simulate the native tissue microenvironment by providing appropriate...
  3. Larger images are better remembered during naturalistic encoding [Psychological and Cognitive Sciences]
    We are constantly exposed to multiple visual scenes, and while freely viewing them without an intentional effort to memorize or encode them, only some are remembered. It has been suggested that image memory is influenced by multiple factors, such as depth of processing, familiarity, and visual category. However, this is...
  4. Reply to Elias et al.: Multiproxy evidence of widespread landscape disturbance in multiple Azorean lakes before the Portuguese arrival [Biological Sciences]
    Despite the multidisciplinary and comprehensive approach taken in ref. 1, we acknowledge that there are still open questions that require further research. We emphasize that our study relies on multiple records that show the synchronous arrival of humans on multiple islands before ca. 1400 CE. Elias et al. (2) raise...
  5. Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack [Immunology and Inflammation]
    Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA), colorectal cancer, and breast cancer are coated with transglutaminase-2 (TGM2)–dependent covalent CXCL12–keratin-19 (KRT19) heterodimers that are organized as filamentous...

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